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Igor E Brodsky Selected Research

Yersinia Infections

10/2021Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection.
11/2020Caspase-8-dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality.
1/2019Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation.
1/2019Analysis of Inflammasome Activation in Response to Yersinia Infection by Fluorescence Microscopy Detection of Active Caspase-1 Puncta.
10/2016Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death.
7/2014IQGAP1 is important for activation of caspase-1 in macrophages and is targeted by Yersinia pestis type III effector YopM.

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Igor E Brodsky Research Topics

Disease

22Infections
01/2022 - 04/2003
6Yersinia Infections
10/2021 - 07/2014
6Inflammation (Inflammations)
11/2020 - 02/2015
6Bacterial Infections (Bacterial Infection)
11/2019 - 08/2009
2Salmonella Infections (Salmonellosis)
01/2022 - 04/2014
2Necrosis
11/2019 - 04/2011
1Neoplasms (Cancer)
12/2022
1Cryptosporidiosis
12/2021
1Toxoplasmosis
11/2019
1Sepsis (Septicemia)
01/2018
1Shock
01/2018
1Endotoxemia
01/2018
1Granuloma
11/2017
1Leishmaniasis
01/2017
1Cutaneous Leishmaniasis
01/2017
1Diarrhea
01/2017
1Plague (Bubonic Plague)
09/2016
1Porcine Reproductive and Respiratory Syndrome (PRRS)
02/2015
1Alzheimer Disease (Alzheimer's Disease)
02/2015
1Parkinson Disease (Parkinson's Disease)
02/2015
1Amyloidosis
02/2015
1Coinfection
01/2014
1Bites and Stings (Sting)
10/2012
1Muscle Cramp (Cramp)
02/2005
1Persistent Infection
02/2005
1Typhoid Fever (Typhoid)
04/2003

Drug/Important Bio-Agent (IBA)

16InflammasomesIBA
01/2022 - 08/2009
8Proteins (Proteins, Gene)FDA Link
01/2021 - 04/2011
5CytokinesIBA
11/2019 - 12/2015
4InterferonsIBA
12/2022 - 01/2014
4Phosphotransferases (Kinase)IBA
01/2019 - 04/2003
4Type III Secretion SystemsIBA
09/2016 - 04/2003
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
12/2022 - 11/2019
3Toll-Like Receptors (Toll-Like Receptor)IBA
11/2019 - 01/2014
3Caspase 8 (Caspase-8)IBA
11/2019 - 10/2016
3Pattern Recognition ReceptorsIBA
11/2016 - 02/2015
2Interferon-gamma (Interferon, gamma)IBA
12/2022 - 02/2005
2LigandsIBA
12/2022 - 01/2022
2Interleukin-18 (Interleukin 18)IBA
12/2021 - 12/2017
2CaspasesIBA
10/2021 - 10/2016
2Virulence Factors (Pathogenicity Factors)IBA
11/2017 - 11/2016
2Interferon Type IIBA
01/2014 - 10/2012
2Peptides (Polypeptides)IBA
02/2005 - 04/2003
1ChemokinesIBA
12/2022
1Immune Checkpoint InhibitorsIBA
12/2022
1lambda Spi-1IBA
01/2022
1Interleukin-1 (Interleukin 1)IBA
10/2021
1Death Domain ReceptorsIBA
11/2020
1Interleukin-12 (IL 12)IBA
11/2019
1sharpinIBA
01/2019
1Biological ProductsIBA
01/2019
1Serine (L-Serine)FDA Link
01/2019
1Caspase 1 (ICE Protease)IBA
01/2019
1LipopolysaccharidesIBA
01/2018
1Interleukin-17 (Interleukin 17)IBA
12/2017
1Toll-Like Receptor 4IBA
12/2015
1Multiprotein ComplexesIBA
02/2015
1Leucine (L-Leucine)FDA Link
02/2015
1NucleotidesIBA
02/2015
1Amyloid (Amyloid Fibrils)IBA
02/2015
1FlagellinIBA
04/2014
1Antiviral Agents (Antivirals)IBA
01/2014
1Pathogen-Associated Molecular Pattern MoleculesIBA
10/2013
1DNA (Deoxyribonucleic Acid)IBA
10/2012
1TNF Receptor-Associated Factor 6 (TRAF6)IBA
04/2011
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
04/2011
1NLR ProteinsIBA
08/2009
1Bacterial Secretion SystemsIBA
08/2009
1cathelinIBA
02/2005
1Membrane Proteins (Integral Membrane Proteins)IBA
02/2005
1Carisoprodol (Soma)FDA LinkGeneric
04/2003

Therapy/Procedure

1Immunotherapy
12/2022